EC Number |
Inhibitors |
Structure |
---|
1.8.1.4 | 1,3-bis(2-chloroethyl)-1-nitrourea |
after reduction of the oxidized form of enzyme to the two-electron-reduced state |
|
1.8.1.4 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine |
at higher concentrations (2 mM) significantly inhibits the lipoamide dehydrogenase activity |
|
1.8.1.4 | 1-methyl-4-phenylpyridinium |
at lower concentrations (1 mM) as compared to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine significantly inhibits the lipoamide dehydrogenase activity |
|
1.8.1.4 | 10-(2-dimethylaminopropyl)-dibenzothiazine cation radical |
60% inactivation after 10 min incubation and 79% after 30 min using the myeloperoxidase system, 72% inactivation after 10 min incubation using the horseradish peroxidase system |
|
1.8.1.4 | 10-(2-methyl,3-dimethylaminopropyl)-dibenzothiazine cation radical |
90% inactivation after 10 min and 30 min incubation using the myeloperoxidase system, 94% inactivation after 10 min incubation using the horseradish peroxidase system |
|
1.8.1.4 | 10-(3-dimethylaminopropyl)-dibenzothiazine cation radical |
87% inactivation after 10 min incubation and 89% after 30 min using the myeloperoxidase system, 94% inactivation after 10 min incubation using the horseradish peroxidase system |
|
1.8.1.4 | 2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridine hydrochloride |
inhibition of NADH-lipoamide oxidoreductase activity, no effect on diaphorase activity and transhydrogenase activity |
|
1.8.1.4 | 2-amino-4-hydroxy-6,7-dimethyl-7,8-dihydropteridine |
inhibition of NADH-lipoamide oxidoreductase activity, no effect on diaphorase activity and transhydrogenase activity |
|
1.8.1.4 | 2-amino-4-hydroxy-6-methyl-7,8-dihydropteridine |
inhibition of NADH-lipoamide oxidoreductase activity, no effect on diaphorase activity and transhydrogenase activity |
|
1.8.1.4 | 2-chloro-10-(3-dimethylaminopropyl)-dibenzothiazine cation radical |
45% inactivation after 10 min incubation and 75% after 30 min using the myeloperoxidase system, 89% inactivation after 10 min incubation using the horseradish peroxidase system |
|