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EC Number
Inhibitors
Commentary
Structure
1.5.8.4
Dimethylthetin
-
1.5.8.4
EDTA
2 mM, 33% inhibition
1.5.8.4
Methoxyacetate
competitive inhibitor at low substrate concentrations
1.5.8.4
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the expressions of 23 genes, including the dimethylglycine dehydrogenase precursor pMe2GlyDH, are significantly down-regulated in the hearts of cardio-specific caspase recruitment domain transgenic mice. Caspase recruitment domain ARC may protect cardiomyocytes from hypoxic cell death by regulating its downstream, dimethylglycine dehydrogenase and developmentally regulated RNA-binding protein Drbp1
1.5.8.4
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Na+, K+, Ca2+, Zn2+, Mn2+, Mg2+, Fe2+, and Co2+ display no or slightly inhibitory effects at 2 mM
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