EC Number   |
Inhibitors |
Structure |
|---|
  1.4.1.B2 | 2,4-Diaminopentanoate |
- |
   |
| 1.4.1.B2 | 2,5-Diaminohexanoate |
- |
|
| 1.4.1.B2 | 5-amino-3-oxohexanoate |
competitive inhibition |
|
| 1.4.1.B2 | ADP |
about half as effective as ATP |
|
| 1.4.1.B2 | AMP |
32% as effective as ATP |
|
| 1.4.1.B2 | arsenate |
addition of any of the neutral salts causes a parabolic inhibition. A direct comparison of arsenate and chloride ion shows that arsenate is not as inhibitory even though it has a higher ionic strength. Arsenate interacts with the enzyme differently from chloride and bromide. Sulfate, which is a large ion like arsenate, is as inhibitory as chloride (at equivalent ionic strength) with NAD+ as coenzyme, but it is much less effective than chloride with NADP+ as coenzyme |
|
| 1.4.1.B2 | ATP |
competitive with respect to L-erythro-3,5-diaminohexanoate and NAD+ |
|
| 1.4.1.B2 | Br- |
addition of any of the neutral salts causes a parabolic inhibition. A direct comparison of arsenate and chloride ion shows that arsenate is not as inhibitory even though it has a higher ionic strength. Arsenate interacts with the enzyme differently from chloride and bromide. Sulfate, which is a large ion like arsenate, is as inhibitory as chloride (at equivalent ionic strength) with NAD+ as coenzyme, but it is much less effective than chloride with NADP+ as coenzyme |
|
| 1.4.1.B2 | Ca2+ |
0.5 mM, 22% inhibition at pH 7.8, cofactor NADP+, activation at pH 8.9 |
|
| 1.4.1.B2 | Cl- |
addition of any of the neutral salts causes a parabolic inhibition. A direct comparison of arsenate and chloride ion shows that arsenate is not as inhibitory even though it has a higher ionic strength. Arsenate interacts with the enzyme differently from chloride and bromide. Sulfate, which is a large ion like arsenate, is as inhibitory as chloride (at equivalent ionic strength) with NAD+ as coenzyme, but it is much less effective than chloride with NADP+ as coenzyme |
|
