EC Number   |
Inhibitors |
Structure |
|---|
    1.4.1.2 | 2-methyl-2,4-pentanediol |
8.5 mM, 94% residual activity. the sequence contains several binding sites for 2-methyl-2,4-pentanediol |
   |
| 1.4.1.2 | 2-Methyleneglutarate |
potent competitive inhibitor |
|
| 1.4.1.2 | 2-oxoglutarate |
substrate inhibition |
|
| 1.4.1.2 | 2-oxoglutarate |
non-competitive versus L-glutamate, competitive versus NAD+ |
|
| 1.4.1.2 | 3,3'-[(2-bromobenzene-1,4-diyl)di(E)ethene-2,1-diyl]bis(6-hydroxybenzoic acid) |
i.e. BSB |
|
| 1.4.1.2 | 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one |
inhibits GDH in a non-competitive manner with the Vmax being greatly affected without a very large change in Km. Crystal structures discloses that 3-(3,5-dibromo)-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one or bithionol, respectively, bind as pairs of stacked compounds at hexameric 2-fold axes between the dimers of subunits |
|
| 1.4.1.2 | 5,5'-dithiobis(2-nitrobenzoate) |
- |
|
| 1.4.1.2 | adipate |
- |
|
| 1.4.1.2 | ADP |
- |
|
| 1.4.1.2 | Al3+ |
inhibits the enzyme activity in the absence of Hg |
|
