EC Number |
Inhibitors |
Structure |
---|
1.3.1.71 | 20-piperidin-2-yl-5alpha-pregnan-20(R),3beta-diol |
i.e. AZA-1, inhibits the enzyme and the DELTA24-sterol methyltransferase, leads to accumulation of ergosta-5,7,24(28)-trien-3beta-ol in vivo |
|
1.3.1.71 | 22-piperidin-2-yl-5alpha-pregnan-3beta,22(S)-diol |
i.e. AZA-2, specific inhibition of the enzyme, leads to accumulatin of ergosta-5,7,22,24(28)-tetraen-3beta-ol in vivo |
|
1.3.1.71 | 22-piperidin-3-yl-5alpha-pregnan-3beta,22(S)-diol |
i.e. AZA-3, inhibits the enzyme, major proliferative effect and accumulation of lanosterol in vivo |
|
1.3.1.71 | 23-Azacholesterol |
0.001 mM, complete inhibition |
|
1.3.1.71 | 23-Azacholesterol |
- |
|
1.3.1.71 | more |
sterol composition with or without addition of azasterol analogue inhibitors, overview |
|