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Results 1 - 10 of 13 > >>
EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.293alpha-adiol - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.295alpha-androstane-3alpha,17beta-diol inhibition of the reaction with dehydroepiandrosterone Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.295alpha-androstane-3alpha,17beta-diol inhibition of the reaction with dehydroepiandrosterone; significantly inhibits CYP7B1-mediated 7alpha-hydroxylation Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.295alpha-Androstane-3beta,17beta-diol inhibits hydroxylation of dehydroepiandrosterone by approximately 60-70% when both steroids are present at equimolar concentrations. A 10fold higher concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture results in the suppression of dehydroepiandrosterone hydroxylation by 80%. In HEK293 cells, the suppressive effect of 5alpha-androstane-3beta,17beta-diol on dehydroepiandrosterone metabolism is statistically significant also at a 10fold lower concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.295alpha-Androstane-3beta,17beta-diol inhibits hydroxylation of dehydroepiandrosterone by approximately 60-70% when both steroids are present at equimolar concentrations. A 10fold higher concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture results in the suppression of dehydroepiandrosterone hydroxylation by 80% Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.29dehydroepiandrosterone inhibits hydroxylation of 5alpha-androstane-3beta,17beta-diol Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.29LY294002 specific inhibitor of phosphatidylinositol 3-kinase, abolishes estrogen receptor-mediated upregulation of a CYP7B1 promoter-luciferase reporter in Hep-G2 cells but not in HEK-293 cells Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.29more no inhibition: testosterone, dehydroepiandrosterone sulfate Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.29more testosterone, dehydroepiandrosterone-sulfate or 22-hydroxycholesterol have little or no effects on CYP7B1-mediated activities Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 1.14.14.29more mRNA encoding CYP39A1 gene is significantly repressed by pregnane X receptor activation in primary hepatocytes of wild-type mice but not in pregnane X receptor-/- hepatocytes Go to the Ligand Summary Page
Results 1 - 10 of 13 > >>