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Results 1 - 10 of 208 > >>
EC Number Inhibitors Commentary Structure
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9(1S,2S)-2-(3,4-dichlorobenzoyl)-cyclopropane-1-carboxylic acid KMO inhibitor UPF 648, totally blocks KMO at 0.1 and 0.01 mM and is still highly active at 0.001 mM (81% inhibition). It reduces 3-hydroxykynurenine synthesis by 64% without affecting kynurenic acid formation. In neuron-depleted striata, UPF 648 decreases both 3-hydroxykynurenine and quinolinic acid production by 77% and 66%, respectively and also raises kynurenic acid synthesis by 27%. 0.1 mM UPF 648 blocks KMO in both lesioned and contralateral striatum, but does not interfere with KAT activity in either tissue Go to the Ligand Summary Page
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9(6-chloro-1H-indazol-1-yl)acetic acid - Go to the Ligand Summary Page
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9(6-chloro-5,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetic acid KMO-inhibitor 1 Go to the Ligand Summary Page
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9(6-chloro-5,7-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetic acid - Go to the Ligand Summary Page
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9(m-nitrobenzoyl)-alanine mNBA, leads to an increase of L-kynurenine and kynurenic acid concentrations in the brain cortex after application in vivo Go to the Ligand Summary Page
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9(m-nitrobenzoyl)-alanine various pyrrolo[3,2-c]quinoline derivates cause enzyme inhibition Go to the Ligand Summary Page
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9(m-nitrobenzoyl)-alanine 50% inhibition at 0.9 micromolar Go to the Ligand Summary Page
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9(R)-3-(5-chloro-2-oxo-6-(1-(pyridin-2-yl)ethoxy)benzo[d]oxazol-3(2H)-yl)propanoate - Go to the Ligand Summary Page
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9(R,S)-2-amino-oxo-4-(3',4'-dichlorophenyl)butanoic acid FCE 28833, 50% inhibition at 0.2 microM, blocks not only the cerebral but also the peripheral enzyme Go to the Ligand Summary Page
Show all pathways known for 1.14.13.9Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.9(R,S)-2-amino-oxo-4-(3'-4'-dichlorophenyl)butanoic acid - Go to the Ligand Summary Page
Results 1 - 10 of 208 > >>