EC Number |
Inhibitors |
Structure |
---|
1.1.1.88 | (3S,6Z)-3-benzyl-1-(4-fluorobenzyl)-8-(4-methoxyphenyl)-4-(3-methylbutanoyl)-3,4,5,8-tetrahydro-1,4-diazocin-2(1H)-one |
purified enzyme, 52.6% residual activity at 0.01 mM |
|
1.1.1.88 | (3S,6Z)-3-benzyl-1-(4-fluorobenzyl)-8-(4-methoxyphenyl)-4-(3-methylbutanoyl)-3,4,5,8-tetrahydro-1,4-diazocin-2(1H)-one |
antiproliferative activity in L-1210 cell, IC50 0.00148 mM |
|
1.1.1.88 | (3S,6Z)-3-benzyl-1-(4-fluorobenzyl)-8-(4-methoxyphenyl)-4-[[(E)-2-phenylethenyl]sulfonyl]-3,4,5,8-tetrahydro-1,4-diazocin-2(1H)-one |
purified enzyme, 32.3% residual activity at 0.01 mM |
|
1.1.1.88 | (3S,6Z)-3-benzyl-1-(4-fluorobenzyl)-8-(4-methoxyphenyl)-4-[[(E)-2-phenylethenyl]sulfonyl]-3,4,5,8-tetrahydro-1,4-diazocin-2(1H)-one |
antiproliferative activity in L-1210 cell, IC50 0.0023 mM |
|
1.1.1.88 | (3S,6Z)-3-benzyl-4-(3,3-dimethylbutanoyl)-1-(4-fluorobenzyl)-8-(4-methoxyphenyl)-3,4,5,8-tetrahydro-1,4-diazocin-2(1H)-one |
purified enzyme, 43.4% residual activity at 0.01 mM |
|
1.1.1.88 | (3S,6Z)-3-benzyl-4-(3,3-dimethylbutanoyl)-1-(4-fluorobenzyl)-8-(4-methoxyphenyl)-3,4,5,8-tetrahydro-1,4-diazocin-2(1H)-one |
antiproliferative activity in L-1210 cell, IC50 0.00143 mM |
|
1.1.1.88 | (3S,6Z)-4-(biphenyl-4-ylsulfonyl)-1-(4-fluorobenzyl)-8-(4-methoxyphenyl)-3-methyl-3,4,5,8-tetrahydro-1,4-diazocin-2(1H)-one |
purified enzyme, 54.4% residual activity at 0.01 mM |
|
1.1.1.88 | (3S,6Z)-4-(biphenyl-4-ylsulfonyl)-1-(4-fluorobenzyl)-8-(4-methoxyphenyl)-3-methyl-3,4,5,8-tetrahydro-1,4-diazocin-2(1H)-one |
antiproliferative activity in L-1210 cell, IC50 0.00119 mM |
|
1.1.1.88 | 3-Hydroxy-3-methylbutyrate |
- |
|
1.1.1.88 | 3-hydroxy-3-methylcarboxylic acid |
competitive inhibitor |
|