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EC Number
Inhibitors
Commentary
Structure
1.1.1.39
(S)-malate
above 10 mM
1.1.1.39
(S)-malate
isozyme NAD-ME2, competitive
1.1.1.39
2-Ketoglutarate
-
1.1.1.39
5'-AMP
isozyme NAD-ME2, competitive versus NAD+, mixed inhibition versus (S)-malate
1.1.1.39
acetyl-CoA
potent inhibitor
1.1.1.39
acetyl-CoA
enzyme activity is allosterically regulated by acetyl-CoA, almost complete inhibition at 0.05 mM
1.1.1.39
acetyl-CoA
-
1.1.1.39
AMP
-
1.1.1.39
ATP
competitive with respect to (S)-malate
1.1.1.39
ATP
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