EC Number   |
Inhibitors |
Structure |
|---|
   1.1.1.30 | (DL)-2-hydroxybutyrate |
5 mM, pH 8.5, 25°, 69% inhibition |
   |
| 1.1.1.30 | (DL)-lactate |
5 mM, pH 8.5, 25°C, 65% inhibition |
|
| 1.1.1.30 | 2,4-Dichlorophenoxyacetic acid |
inhibits the enzyme, in vivo treatment of the animals with 2,4-dichlorophenoxyacetic acid leads to strong decrease of triglycerides level and HDL cholesterol and an increase in GOT level and LDL cholesterol, and necrosis of seminiferous tubules cells in testis, hyperplasia of hepatocytes in liver and presence of multinucleated giant cells in brain, overview |
|
| 1.1.1.30 | 2-Hydroxybutyrate |
10 mM, 57% inhibition |
|
| 1.1.1.30 | 2-oxobutyrate |
10 mM, 29% inhibition |
|
| 1.1.1.30 | 3-hydroxybutyrate |
substrate inhibition at concentrations above 20 mM, 50% inhibition at 200 mM, cyanylated enzyme is 3fold more active at high substrate concentration |
|
| 1.1.1.30 | 4-mercapto-3-nitrobenzoate |
derivatization of enzyme sulfhydryl groups, less than 1% residual activity |
|
| 1.1.1.30 | 5,5'-dithiobis(2-nitrobenzoic acid) |
0.15 mM, 63% inhibition |
|
| 1.1.1.30 | acetoacetate |
substrate inhibition, above 5 mM, noncompetitive vs. NADH |
|
| 1.1.1.30 | acetoacetate |
inhibition above 1 mM, 2 mM, 89% inhibition |
|
