EC Number   |
Inhibitors |
Structure |
|---|
    1.1.1.132 | 5'-(3-hydroxypropyl)-amino-5'-deoxy-guanosine |
only after preincubation with enzyme |
   |
| 1.1.1.132 | 5'-azido-5'-deoxy-guanosine |
only after preincubation with enzyme |
|
| 1.1.1.132 | 5'-azido-5'-deoxy-N2-2',3'-O-triacetylguanosine |
only after preincubation with enzyme |
|
| 1.1.1.132 | 5'[[[[(2'',3'',4'',6''-tetra-O-acetyl 6''-ethynyl)alpha-D-mannopyranosyl oxy]-carbonyl]amino]sulfonyl]-2',3'-isopropylidene N2-acetyl guanosine |
GDP-analog, 0.1 mM, 60% inhibition |
|
| 1.1.1.132 | ambroxol |
i.e. 2-amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzylamine, inhibits GMD activity, reduces the production of alginate, the expression of the important genes, and affects the structure of mucoid Pseudomonas aeruginosa biofilms, overview; reduces activity of the key enzyme GMD in alginate biosynthesis in a concentration-dependent manner |
|
| 1.1.1.132 | ATP |
26% inhibition at 1 mM |
|
| 1.1.1.132 | C6-amido-GDP-D-mannose |
mixed mechanism of inhibition |
|
| 1.1.1.132 | Ca2+ |
inhibitor of isoform GMD2 with 71.86% residual activity at 1 mM |
|
| 1.1.1.132 | D-maltose |
17% inhibition at 1 mM |
|
| 1.1.1.132 | erythromycin |
potent dose-dependent inhibitory effect, inhibition of biofilm formation, PT-1578 |
|
