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Results 1 - 10 of 16 > >>
EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.71more aryl (beta-amino)ethyl ketones inhibit sortase enzymes. Inhibition of sortases occurs through an irreversible, covalent modification of their active site cysteine. Sortases specifically activate this class of molecules via beta-elimination, generating a reactive olefin intermediate that covalently modifies the cysteine thiol Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.71quercetin IC50 for recombinant SrtB(DELTA30): 0.03328 mM, no antibacterial activity against Staphylococcus aureus Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.71kaempferol IC50 for recombinant SrtB(DELTA30): 0.02455 mM, no antibacterial activity against Staphylococcus aureus Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.71myricetin IC50 for recombinant SrtB(DELTA30): 0.03689 mM, no antibacterial activity against Staphylococcus aureus Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.71morin IC50 for recombinant SrtB(DELTA30): 0.00854 mM, no antibacterial activity against Staphylococcus aureus Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.71phloretin compound shows little anti-Staphylococcus aureus activity, but significantly inhibit SrtB activity in vitro. Phloretin reduces human alveolar epithelial cell damage caused by Staphylococcus aureus. Phloretin directly localizes in the active pocket of SrtB and blocks substrate binding Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.71isorhamnetin IC50 for recombinant SrtB(DELTA30): 0.04335 mM, no antibacterial activity against Staphylococcus aureus Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.71galangin IC50 for recombinant SrtB(DELTA30): 0.03837 mM, no antibacterial activity against Staphylococcus aureus Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.71coptisine coptisine can bind to the active pocket of SrtB, residues Arg115, Asn116, and Ile182 play a vital role in the interaction of SrtB with coptisine. Coptisine can reduce the adhesion of Staphylococcus aureus to human lung epithelial cells Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.71berberine chloride potential of this inhibitor for the treatment of Staphylococcus aureus infections Go to the Ligand Summary Page
Results 1 - 10 of 16 > >>