EC Number   |
Inhibitors |
Structure  |
|---|
   3.4.22.55 | more |
KM-values above 0.01 mM are obtained with acetyl-WEHD-aldehyde, acetyl-YVAD-aldehyde, acetyl-AEVD-aldehyde or cowpox serpin CrmA |
 |
| 3.4.22.55 | more |
caspase-2 is not subject to inhibition by members of the IAP family of apoptosis inhibitors |
|
| 3.4.22.55 | more |
siRNA directed at caspase-2, inhibits TRAIL-induced cell death |
|
| 3.4.22.55 | acetyl-DEVD-aldehyde |
- |
  |
| 3.4.22.55 | acetyl-IETD-aldehyde |
- |
|
| 3.4.22.55 | benzyloxycarbonyl-VAD-fluoromethylketone |
t1/2 at 0.001 mM is 40 min |
|
| 3.4.22.55 | SP600125 |
inhibits caspase-2 partially |
|
| 3.4.22.55 | coenzyme Q10 |
- |
|
| 3.4.22.55 | Z-Val-Ala-Asp-fluoromethylketone |
pan-caspase inhibitor |
|
| 3.4.22.55 | amyloid beta |
treatment of rat hippocampal neuron extracts with either 300 nM or 0.001 mM amyloid beta leads to activation of caspase-2 |
|
