EC Number   |
Inhibitors |
Structure  |
|---|
   3.4.19.1 | more |
alphabeta peptide (1-40) can inhibit APH activity from the cell lysates of APH transfected cells after IP at 0.01 and 0.001 mM concentration, while reversed alphabeta peptide (40-1) at the same concentrations does not show any inhibitory effect |
 |
| 3.4.19.1 | more |
acylpeptide hydrolase is a direct target for some organophosphate compounds |
|
| 3.4.19.1 | more |
different organophosphorous compounds bind to the enzyme inducing conformational changes in two domains, namely, alpha/beta hydrolase and beta-propeller, computational study of APH bound to chlorpyrifosmethyl oxon and dichlorvos, and molecular dynamics simulations of enzyme bound to the inhibitors, the starting model of APH is derived from 2.7 A resolution crystal structure of acylpeptide hydrolase/esterase from Aeropyrum pernix K1 (PDB ID 1VE7), overview. The docking study reveals that Val471 and Gly368 are important residues for chlorpyrifosmethyl oxon and dichlorvos binding |
|
| 3.4.19.1 | Zn2+ |
1 mM, complete inhibition of recombinant enzyme |
  |
| 3.4.19.1 | Zn2+ |
most potent inhibitor |
|
| 3.4.19.1 | Cu2+ |
- |
|
| 3.4.19.1 | Cu2+ |
1 mM, complete inhibition of recombinant enzyme |
|
| 3.4.19.1 | EDTA |
1 mM, 10% inhibition |
|
| 3.4.19.1 | Hg2+ |
- |
|
| 3.4.19.1 | Hg2+ |
HgCl2 |
|
