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EC Number
Inhibitors
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Structure
3.4.18.1
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recombinant proPoCtX is inhibited by antipain and leupeptin
3.4.18.1
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the addition of the specific MEK1/2 inhibitor U0126 reduces Helicobacter pylori-stimulated CTSX expression in U937 monocytes, but not in NCI-N87 cells. In NCIN87 cells, the regulation is controlled by p38 and JNK. Inhibition by SB203580 and SP600125 completely abolish the stimulated CTSX protein expression of NCI-N87 cells in response to Helicobacter pylori infection
3.4.18.1
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inhibition of cathepsin X with either AMS36 or 2F12mAb
3.4.18.1
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cathepsin X inhibiting 2F12 mAb
3.4.18.1
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cathepsin X inhibition by mAb 2F12. Migration of primary T cell is reduced by mAb 2F12 by 0.27fold
3.4.18.1
Cu2+
1 mM, 93% inhibition
3.4.18.1
EDTA
0.1 mM, proPoCtX: 5.1% inhibition, native PoCtX: 14.2% inhibition
3.4.18.1
EDTA
0.1 mM, 86% inhibition
3.4.18.1
Co2+
1 mM, 71% inhibition
3.4.18.1
Hg2+
1 mM, 90% inhibition
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