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Results 1 - 10 of 87 > >>
EC Number Inhibitors Commentary Structure
Show all pathways known for 2.5.1.19Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.19(3R,4S,5R)-4-hydroxy-5-[(2R)-1-hydroxy-1-oxo-2-phosphono-propan-2-yl]oxy-3-phosphonooxy-cyclohexene-1-carboxylic acid RP-TI, (R)-phosphonate analogue of the (S)-tetrahedral reaction intermediate, competitive inhibitor of EPSPS forward reaction, 460fold decrease in potency compared to glyphosate-sensitive class I EPSPS from Escherichia coli Go to the Ligand Summary Page
Show all pathways known for 2.5.1.19Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.19(3R,4S,5R)-4-hydroxy-5-[(2R)-1-hydroxy-1-oxo-2-phosphono-propan-2-yl]oxy-3-phosphonooxy-cyclohexene-1-carboxylic acid RP-TI, (R)-phosphonate analogue of the (S)-tetrahedral reaction intermediate, very potent competitive inhibitor of EPSPS forward reaction, binding induces substantial conformational change in enzyme’s backbone and active site (e.g., Glu341 and Arg124) Go to the Ligand Summary Page
Show all pathways known for 2.5.1.19Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.19(3R,4S,5R)-4-hydroxy-5-[(2R)-1-hydroxy-1-oxo-2-phosphono-propan-2-yl]oxy-3-phosphonooxy-cyclohexene-1-carboxylic acid RP-TI, (R)-phosphonate analogue of the (S)-tetrahedral reaction intermediate, competitive inhibitor of EPSPS forward reaction, 120-fold decrease in potency compared to glyphosate-sensitive class I EPSPS from Escherichia coli Go to the Ligand Summary Page
Show all pathways known for 2.5.1.19Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.19(3R,4S,5R)-4-hydroxy-5-[(2S)-1-hydroxy-1-oxo-2-phosphono-propan-2-yl]oxy-3-phosphonooxy-cyclohexene-1-carboxylic acid SP-TI, (S)-phosphonate analogue of the (S)-tetrahedral reaction intermediate, non-potent competitive inhibitor of EPSPS forward reaction Go to the Ligand Summary Page
Show all pathways known for 2.5.1.19Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.19(3R,4S,5R)-4-hydroxy-5-[(2S)-1-hydroxy-1-oxo-2-phosphono-propan-2-yl]oxy-3-phosphonooxy-cyclohexene-1-carboxylic acid SP-TI, (S)-phosphonate analogue of the (S)-tetrahedral reaction intermediate, moderate competitive inhibitor of EPSPS forward reaction Go to the Ligand Summary Page
Show all pathways known for 2.5.1.19Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.19(3R,4S,5R)-4-hydroxy-5-[(2S)-1-hydroxy-1-oxo-2-phosphono-propan-2-yl]oxy-3-phosphonooxy-cyclohexene-1-carboxylic acid SP-TI, (S)-phosphonate analogue of the (S)-tetrahedral reaction intermediate, competitive inhibitor of EPSPS forward reaction Go to the Ligand Summary Page
Show all pathways known for 2.5.1.19Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.19(3R,4S,5R)-5-((R)-1-carboxy-1-phosphono-ethoxy)-4-hydroxy-3-phosphonooxy-cyclohex-1-enecarboxylic acid analogue of the tetrahedral reaction intermediate, competitive to both substrates, binding structure analysis, binding induces conformational changes to residues Arg124 and Glu341 within the active site, which results in structural alterations in the amino-terminal globular domain of the enzyme Go to the Ligand Summary Page
Show all pathways known for 2.5.1.19Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.19(3R,4S,5R)-5-((S)-1-carboxy-1-phosphono-ethoxy)-4-hydroxy-3-phosphonooxy-cyclohex-1-enecarboxylic acid analogue of the tetrahedral reaction intermediate, competitive to both substrates, binding structure analysis, binding induces no conformational changes Go to the Ligand Summary Page
Show all pathways known for 2.5.1.19Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.19(3R,4S,5R)-5-[(2R)-1,1-difluoro-3-hydroxy-3-oxo-2-phosphonooxy-propan-2-yl]oxy-4-hydroxy-3-phosphonooxy-cyclohexene-1-carboxylic acid 2F-TI, (R)-difluoromethyl analogue of the (S)-tetrahedral reaction intermediate, competitive inhibitor of EPSPS forward reaction, 8fold decrease in potency compared to glyphosate-sensitive class I EPSPS from Escherichia coli Go to the Ligand Summary Page
Show all pathways known for 2.5.1.19Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.19(3R,4S,5R)-5-[(2R)-1,1-difluoro-3-hydroxy-3-oxo-2-phosphonooxy-propan-2-yl]oxy-4-hydroxy-3-phosphonooxy-cyclohexene-1-carboxylic acid 2F-TI, (R)-difluoromethyl analogue of the (S)-tetrahedral reaction intermediate, very potent competitive inhibitor of EPSPS forward reaction Go to the Ligand Summary Page
Results 1 - 10 of 87 > >>