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Results 1 - 10 of 13 > >>
EC Number
Inhibitors
Commentary
Structure
arsenite
the enzyme activity is completely inhibited by elevated concentrations of the substrate arsenite (0.2 mM)
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dimethylselenoxide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
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glutathione
addition of 20 mM GSH sharply inhibits methylation
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GSH
suppression of formation of trimethylarsine oxide, stimulatory effect on the rate of methylarsonate and dimethylarsinate production from arsenite is concentration-dependent
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GSH
addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite
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HgCl2
-
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methylselenic acid
-
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selenate
more than 1 mM selenate necessary for 50% inhibition
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Selenite
50% inhibition with 0.0126 mM selinite
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Selenite
addition of selenite at 1:10 molar ratio with arsenite in the reaction mixture completely abolishes the arsenic methylation
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Results 1 - 10 of 13 > >>