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EC Number
Inhibitors
Commentary
Structure
1.5.5.2
more
no enzyme inhibibtion by atpenin A5, an inhibitor of Complex II
1.5.5.2
pyruvate
-
1.5.5.2
acetate
competitive
1.5.5.2
succinate
uncompetitive inhibitor, in the presence of low levels of proline in vivo, higher levels of succinate can act to inhibit PRODH/POX activity and reactive oxygena species generation. The affinity of succinate is for the enzyme-substrate complex of PRODH/POX and proline rather than for the enzyme binding site for proline. Succinate protects electron transport chain component proteins from PRODH/POX reactive oxygen species-mediated downregulation with almost the same efficacy as 3,4-dehydro-L-proline and N-acetyl-L-cysteine
1.5.5.2
cyanide
only membrane-associated enzyme, not soluble enzyme
1.5.5.2
KCN
very strong inhibition
1.5.5.2
L-proline
substrate inhibition at high L-proline concentrations; substrate inhibition at high L-proline concentrations
1.5.5.2
L-proline
substrate inhibition at high L-proline concentrations
1.5.5.2
L-lactate
-
1.5.5.2
L-lactate
competitive
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