EC Number   |
Inhibitors |
Structure  |
|---|
    1.14.99.1 | more |
effect of cofactor, enzyme and substrate concentration on inhibition by human serum, haptoglobin and albumin |
 |
| 1.14.99.1 | more |
mechanism of selective inhibition |
|
| 1.14.99.1 | more |
nimesulide inhibits PGHS-2 turnover in most brain regions |
|
| 1.14.99.1 | more |
guava leaf extract inhibits the catalytic activity of the PGHS-1 isoform using linoleic acid as substrate (IC50 value of 0.055 mg of dry leaf extract); guava leaf extract inhibits the catalytic activity of the PGHS-2 isoform using linoleic acid as substrate (IC50 value of 0.56 mg of dry leaf extract); isozyme PGHS-1 is hardly inhibited by ellagic acid; isozyme PGHS-2 is hardly inhibited by ellagic acid |
|
| 1.14.99.1 | more |
guava leaf extract inhibits the catalytic activity of the PGHS-1 and PGHS-2 isoforms using linoleic acid as substrate; guava leaf extract inhibits the catalytic activity of the PGHS-1 and PGHS-2 isoforms using linoleic acid as substrate; isozyme PGHS-1 is hardly inhibited by ellagic acid; isozyme PGHS-2 is hardly inhibited by ellagic acid |
|
| 1.14.99.1 | more |
algal PGHS is not inhibited by non-steroidal anti-inflammatory drugs that inhibit the mammalian enzymes |
|
| 1.14.99.1 | more |
no inhibition of PGHS-2 oxygenase activity by 9-nitro-, 12-nitro-, 14-nitro, and 15-nitroarachidonic acid and by nitrooleic acid and nitrolinoleic acid; other nitro fatty acids tested, such as nitrooleic acid and nitrolinoleic acid, are unable to inhibit the enzyme activity |
|
| 1.14.99.1 | O2 |
the cyclooxygenase reaction is inhibited by an excess of dissolved oxygen, 0.5 mM O2 causes twofold decrease in the initial rate and maximal yield |
  |
| 1.14.99.1 | EDTA |
weak |
|
| 1.14.99.1 | dithiothreitol |
inhibition of prostaglandin G1 synthesis |
|
