EC Number |
Inhibitors |
Structure |
---|
1.14.14.29 | 3alpha-adiol |
- |
|
1.14.14.29 | 5alpha-androstane-3alpha,17beta-diol |
inhibition of the reaction with dehydroepiandrosterone |
|
1.14.14.29 | 5alpha-androstane-3alpha,17beta-diol |
inhibition of the reaction with dehydroepiandrosterone; significantly inhibits CYP7B1-mediated 7alpha-hydroxylation |
|
1.14.14.29 | 5alpha-Androstane-3beta,17beta-diol |
inhibits hydroxylation of dehydroepiandrosterone by approximately 60-70% when both steroids are present at equimolar concentrations. A 10fold higher concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture results in the suppression of dehydroepiandrosterone hydroxylation by 80%. In HEK293 cells, the suppressive effect of 5alpha-androstane-3beta,17beta-diol on dehydroepiandrosterone metabolism is statistically significant also at a 10fold lower concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture |
|
1.14.14.29 | 5alpha-Androstane-3beta,17beta-diol |
inhibits hydroxylation of dehydroepiandrosterone by approximately 60-70% when both steroids are present at equimolar concentrations. A 10fold higher concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture results in the suppression of dehydroepiandrosterone hydroxylation by 80% |
|
1.14.14.29 | dehydroepiandrosterone |
inhibits hydroxylation of 5alpha-androstane-3beta,17beta-diol |
|
1.14.14.29 | LY294002 |
specific inhibitor of phosphatidylinositol 3-kinase, abolishes estrogen receptor-mediated upregulation of a CYP7B1 promoter-luciferase reporter in Hep-G2 cells but not in HEK-293 cells |
|
1.14.14.29 | more |
no inhibition: testosterone, dehydroepiandrosterone sulfate |
|
1.14.14.29 | more |
testosterone, dehydroepiandrosterone-sulfate or 22-hydroxycholesterol have little or no effects on CYP7B1-mediated activities |
|
1.14.14.29 | more |
mRNA encoding CYP39A1 gene is significantly repressed by pregnane X receptor activation in primary hepatocytes of wild-type mice but not in pregnane X receptor-/- hepatocytes |
|