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Results 1 - 10 of 13 > >>
EC Number
Inhibitors
Commentary
Structure
3alpha-adiol
-
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5alpha-androstane-3alpha,17beta-diol
inhibition of the reaction with dehydroepiandrosterone
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5alpha-androstane-3alpha,17beta-diol
inhibition of the reaction with dehydroepiandrosterone; significantly inhibits CYP7B1-mediated 7alpha-hydroxylation
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5alpha-Androstane-3beta,17beta-diol
inhibits hydroxylation of dehydroepiandrosterone by approximately 60-70% when both steroids are present at equimolar concentrations. A 10fold higher concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture results in the suppression of dehydroepiandrosterone hydroxylation by 80%. In HEK293 cells, the suppressive effect of 5alpha-androstane-3beta,17beta-diol on dehydroepiandrosterone metabolism is statistically significant also at a 10fold lower concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture
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5alpha-Androstane-3beta,17beta-diol
inhibits hydroxylation of dehydroepiandrosterone by approximately 60-70% when both steroids are present at equimolar concentrations. A 10fold higher concentration of 5alpha-androstane-3beta,17beta-diol than of dehydroepiandrosterone in the incubation mixture results in the suppression of dehydroepiandrosterone hydroxylation by 80%
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dehydroepiandrosterone
inhibits hydroxylation of 5alpha-androstane-3beta,17beta-diol
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LY294002
specific inhibitor of phosphatidylinositol 3-kinase, abolishes estrogen receptor-mediated upregulation of a CYP7B1 promoter-luciferase reporter in Hep-G2 cells but not in HEK-293 cells
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no inhibition: testosterone, dehydroepiandrosterone sulfate
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testosterone, dehydroepiandrosterone-sulfate or 22-hydroxycholesterol have little or no effects on CYP7B1-mediated activities
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mRNA encoding CYP39A1 gene is significantly repressed by pregnane X receptor activation in primary hepatocytes of wild-type mice but not in pregnane X receptor-/- hepatocytes
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Results 1 - 10 of 13 > >>