EC Number   |
Inhibitors |
Structure  |
|---|
    1.13.11.27 | more |
neither epoxybenzoaquinone ester nor 2-hydroxy-3-phenyl-3-butenoic acid is an inhibitor |
 |
| 1.13.11.27 | more |
the enzyme is molecular target of new families of potent herbicides |
|
| 1.13.11.27 | more |
[1-tert-butyl-3-(2,4-dichlorophenyl)-5-hydroxy-1H-pyrazol-4-yl][2-chloro-4-(methylsulfonyl)phenyl]methanone, no significant inhibition up to 0.02 mM |
|
| 1.13.11.27 | more |
high-throughput screening of 4-hydroxyphenylpyruvate dioxygenase inhibitors |
|
| 1.13.11.27 | more |
inhibition mechanism of enzyme HPPD, detailed overview |
|
| 1.13.11.27 | more |
structure-based design of a series of pyrazolone-quinazolone hybrids, as a class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors, synthesis, overview. Molecular modeling indicates that the interaction between the pyrazolone ring and ferrous ion, and the hydrophobic interaction of quinazolone with its surrounding residues, such as Phe347 and Phe364, contribute greatly to the high potency of these inhibitors. Compounds N-(4-methoxyphenyl)-7-nitro-2,1,3-benzoxadiazol-4-amine and 3-(2-bromo-4-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one can be potentially useful for the treatment of type I tyrosinemia and other diseases with defects in tyrosine degradation |
|
| 1.13.11.27 | more |
synthesis of pyrazole-benzimidazolone hybrids from DNS869 and droperidol, bioevaluation of pyrazole-benzimidazolone hybrids as human 4-hydroxyphenylpyruvate dioxygenase inhibitors, overview |
|
| 1.13.11.27 | more |
design, synthesis, and herbicidal activity of triketone-quinoline hybrids as 4-hydroxyphenylpyruvate dioxygenase inhibitors, overview. Computational modeling and CoMSIA analysis |
|
| 1.13.11.27 | more |
efficient one-pot synthesis of 2-(aryloxyacetyl)cyclohexane-1,3-diones as herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors, overview |
|
| 1.13.11.27 | more |
enzyme inhibition mechanisms and binding structures, molecular docking study, overview |
|
