EC Number   |
Inhibitors |
Structure |
|---|
    4.2.1.3 | ATP |
- |
   |
| 4.2.1.3 | Cd2+ |
exposure of isolated mitochondria to 0.05 mM Cd2+ results in 20-25% inhibition of mitochondrial aconitase activity. Exposure of whole oysters to Cd2+ for 3-6 weeks has no effect on aconitase activity |
|
| 4.2.1.3 | Cd2+ |
inactivation of enzyme, particularly at elevated temperature |
|
| 4.2.1.3 | citramalate |
a competitive inhibitor of aconitase activity; a competitive inhibitor of aconitase activity; a competitive inhibitor of aconitase activity |
|
| 4.2.1.3 | citramalate |
an endogenous compound of fruit pulp, is a competitive endogenous inhibitor of citrus aconitase, it significantly increases citrate content and reduces the mitochondrial isozyme activity, while slightly inducing its protein level |
|
| 4.2.1.3 | citrate |
citrate accumulation under enzyme inhibition restricts the formation of hydroxyl radical in the Fenton reaction through the binding of iron ions, and it thus protects the enzyme from inactivation |
|
| 4.2.1.3 | D-glucose 1-phosphate |
- |
|
| 4.2.1.3 | D-glucose 6-phosphate |
- |
|
| 4.2.1.3 | deferiprone |
the loss of aconitase activity observed in cells should be ascribed to the chelation of available iron rather than to a direct effect of the chelator on the iron-sulfur clusters of the enzyme |
|
| 4.2.1.3 | EDTA |
- |
|
