EC Number   |
Inhibitors |
Structure |
|---|
  3.6.1.8 | licnofolide |
0.065 mg/ml, 22% inhibition |
   |
| 3.6.1.8 | licoflavone B |
isolated from Glycyrrhiza inflata, possesses high in vitro schistosomicidal activity against adult worms of Schistosoma mansoni. Licoflavone B causes massive damage in the worm's tegument and inhibits egg laying, without affecting mammalian Vero cells. The tegument of Schistosoma mansoni is crucial for the parasite survival and its host immune defense. Licoflavone B is highly effective in inhibiting Schistosoma mansoni ATP diphosphohydrolase, docking studies with licoflavone B and SmATPase 1 revealing a spontaneous process. The docking study predicts different interactions between licoflavone B and ATPDase 1, corroborating with the in vitro inhibitory activity. Licoflavone B also shows inhibitory activity against ATPase in Schistosoma mansoni |
|
| 3.6.1.8 | more |
no inhibition by 0.065 mg/ml 15-desoxygoyazensolide |
|
| 3.6.1.8 | more |
in vitro schistosomicidal activity of the crude extract of Glycyrrhiza inflata roots containing echinatin, licoflavone A and licoflavone B |
|
| 3.6.1.8 | phosphatidylserine |
- |
|
| 3.6.1.8 | thapsigargicin |
0.065 mg/ml, 57% inhibition |
|
| 3.6.1.8 | thapsigargin |
inhibits ATP hydrolysis, 70% inhibition at 0.065 mg/ml, mixed type inhibition, little or not affected by changes in free Ca2+ or Mg2+ concentrations, hydrolysis of ADP is not inhibited |
|
| 3.6.1.8 | UDPGlc |
very weak |
|
