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EC Number
Inhibitors
Commentary
Structure
3.4.23.49
calf thymus histone H2B
growth inhibitory activity against bacterial gene expressing Escherichia coli with calculated 50% growth inhibitory concentrations of 3.8 microM. Histone H2B penetrates the cell membrane of JCM5491 OmpT+ cells
3.4.23.49
calf thymus histone H3
growth inhibitory activity against bacterial gene expressing Escherichia coli with calculated 50% growth inhibitory concentrations of 10 microM. Histones H3 and H4 remain on the cell surface and subsequently disrupt the cell membrane structure with bleb formation in a manner similar to general antimicrobial peptides
3.4.23.49
calf thymus histone H4
growth inhibitory activity against bacterial gene expressing Escherichia coli with calculated 50% growth inhibitory concentrations of 12.7 microM. Histones H3 and H4 remain on the cell surface and subsequently disrupt the cell membrane structure with bleb formation in a manner similar to general antimicrobial peptides
3.4.23.49
Co2+
-
3.4.23.49
Cu2+
-
3.4.23.49
Cu2+
CuCl2
3.4.23.49
Cu2+
1 mM, 77% residual activity
3.4.23.49
Cu2+
enzyme binding study
3.4.23.49
CuCl2
significant inhibition at 1 mM
3.4.23.49
darunavir
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Results
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