EC Number   |
Inhibitors |
Structure |
|---|
   3.4.22.34 | 2,2-dimethyl-propionic acid 3-benzyloxycarbonylamino-4-carbamoyl-2-oxo-butyl ester |
weak inhibition |
   |
| 3.4.22.34 | 2,6-dimethyl-benzoic acid 3-benzyloxycarbonylamino-4-carbamoyl-2-oxo-butyl ester |
enters cells and causes complete, irreversible inhibition of the enzyme, inhibition of autocatalytic processing in vivo |
|
| 3.4.22.34 | 2-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]piperidine-1-carboxylic acid |
- |
|
| 3.4.22.34 | 3-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]-3,4-dihydroisoquinoline-2(1H)-carboxylic acid |
- |
|
| 3.4.22.34 | 4-(2-aminoethyl) benzenesulfonyl fluoride |
AEBSF, 45.8% inhibition at 5 mM |
|
| 3.4.22.34 | 4-chloromercuribenzoate |
- |
|
| 3.4.22.34 | 4-[[(2S)-2-([2-(2-amino-2-oxoethyl)-2-[(2E)-4-ethoxy-4-oxobut-2-enoyl]hydrazinyl]carbonyl)pyrrolidin-1-yl]carbonyl]-1,3-thiazolidine-3-carboxylic acid |
- |
|
| 3.4.22.34 | Ac-Tyr-Val-Ala-Asp-chloromethylketone |
the rate of inhibition by Asp-CMK is approximately 3times more rapid at pH 4.0 than at pH 5.5 |
|
| 3.4.22.34 | acetyl-Glu-Ser-Glu-Asn-aldehyde |
hydrolysis of the the Asn-containing substrate inhibited in a concentration-dependent manner |
|
| 3.4.22.34 | Acetyl-Tyr-Val-Ala-Asp-aldehyde |
hydrolysis of the the Asn-containing substrate inhibited in a concentration-dependent manner, reduced amounts of cyclic cyclotide produced in transiently transformed tobacco leaves determined |
|
