EC Number   |
Inhibitors |
Structure |
|---|
   2.7.1.105 | 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one |
(3PO), small-molecule inhibitor, mixed inhibition mechanism, both competitive and uncompetitive inhibition, suppresses glycolytic flux and is cytostatic to neoplastic cells, inhibits activity of recombinantly expressed PFKFB3 |
   |
| 2.7.1.105 | 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one |
- |
|
| 2.7.1.105 | 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one |
the PFKFB3 inhibitor, 3PO, increases p27 protein in Lewis lung carcinoma cells in vitro and in vivo |
|
| 2.7.1.105 | 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one |
3PO, a weak competitive inhibitor of PFKFB3, reduces the glucose metabolism and proliferation of cancer cells |
|
| 2.7.1.105 | 3-phosphoglycerate |
- |
|
| 2.7.1.105 | 3H-benzo[e]indol-2-yl(pyridin-4-yl)methanone |
- |
|
| 2.7.1.105 | 4-(4-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-5-bromo-6-oxopyridazin-1(6H)-yl)benzonitrile |
- |
|
| 2.7.1.105 | 4-bromo-2-phenyl-5-(((tetrahydrofuran-2-yl)methyl)amino)pyridazin-3(2H)-one |
- |
|
| 2.7.1.105 | 4-bromo-2-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridazin-3(2H)-one |
- |
|
| 2.7.1.105 | 4-bromo-5-morpholino-2-phenylpyridazin-3(2H)-one |
- |
|
