EC Number |
Inhibitors |
Structure |
---|
1.1.1.3 | L-threonine |
the enzyme activity is subjected to feedback regulation by L-threonine |
|
1.1.1.3 | L-threonine |
the natural threonine binding sites of the enzyme are predicted and verified by mutagenesis experiments |
|
1.1.1.3 | L-threonine |
allosteric inhibitor |
|
1.1.1.3 | L-valyl-5-hydroxy-4-oxo-L-norvaline |
i.e. (S)-2-N-[(S)-valyl]amino-5-hydroxy-4-oxopentanoic acid |
|
1.1.1.3 | lysine |
- |
|
1.1.1.3 | methionine |
- |
|
1.1.1.3 | methionine |
weakly inhibits reverse but not forward reaction |
|
1.1.1.3 | more |
no inhibition by [2-(1,1-dimethylethyl)-4-[[5-(1,1-dimethylethyl)-4-hydroxy-2-methylphenyl]thio]-5-methylphenoxy]-acetic acid and 4-amino-butyric acid 2-tert-butyl-4-(3-tert-butyl-4-hydroxy-phenylsulfanyl)-phenyl ester |
|
1.1.1.3 | more |
Thr does not inhibit homoserine dehydrogenase 1 |
|
1.1.1.3 | more |
Lys, Met, and S-2-aminoethyl-L-cysteine do not affect HSDH activity at 1-5 mM |
|