EC Number   |
Activating Compound |
Reference |
|---|
    6.3.2.3 | activator protein 1 |
i.e. AP-1, mediates the induction of enzyme expression by tert-butylhydroquinone, binds to the enzyme promotor, antagonisted by c-jun, a dominant negative which is also produced in enhanced levels after treatment with tert-butylhydroquinone |
652304 |
| 6.3.2.3 | buthionine sulfoximine |
increase in enzyme expression in hepatocytes by 2.55fold after 18 h |
650330 |
| 6.3.2.3 | diethyl maleate |
increase in enzyme expression in hepatocytes 1.6fold |
650330 |
| 6.3.2.3 | monocrotaline |
treatment of rats with monocrotaline, a pyrrolizidine alkaloid, increases the activity of GS |
694059 |
| 6.3.2.3 | more |
(-)epicatechin upregulates the anti-oxidant response element, ARE, via an phosphatidylinositol 3-kinase-dependent pathway, ARE promotes the expression of protective proteins including those required for glutathione synthesis, i.e. the xCT cystine antiporter, gamma-glutamylcysteine synthetase and glutathione synthase, in cortical astrocytes, but not in neurons, overview, cyclic AMP response element and 3'-O-methyl-epicatechin play no significant role in enzyme upregulation |
693731 |
| 6.3.2.3 | more |
enzyme expression in not affected by insulin and hydrocortisone treatment or by ethanol-feeding, a partial hepatectomy lead to increase in enzyme expression 2.7fold after 12 h |
650330 |
| 6.3.2.3 | more |
folate and vitamin E depletion leads to 18% increased enzyme expression and activity, mice mutants lacking apolipoprotein E show even higher activation rates of 31% on minimal diet compared to the wild-type on normal diet |
652983 |
| 6.3.2.3 | more |
oxidative stress induces the enzyme, key transcription factors include Nrf2/Nrf1 via the antioxidant response element, ARE, activator protein-1, AP-1, and nuclear factor kappa B, NFkappaB. Basal expression requires AP-1 and NFkappaB |
694059 |
| 6.3.2.3 | more |
oxidative stress induces the enzyme, key transcription factors include Nrf2/Nrf1 via the antioxidant response element, ARE, activator protein-1, AP-1, and nuclear factor kappa B, NFkappaB. Nrf1 and Nrf2 overexpression induces the human GS promoter activity |
694059 |
| 6.3.2.3 | more |
oxidative stress induces the enzyme, key transcription factors include Nrf2/Nrf1 via the antioxidant response element, ARE, activator protein-1, AP-1, and nuclear factor kappa B, NFkappaB. Nrf1 is required for basal expression of GS in the mouse |
694059 |
