6.3.1.1 | more |
the unfolded protein response, UPR, pathway is comprised of three signaling cascades, mediated by the ER stress sensor proteins PERK, IRE1, and ATF6, and PERK is responsible for activation of the ASNS, while the IRE1/XBP1 and ATF6 branches of the UPR do not participate in the induction of ASNS transcription, overview |
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