EC Number   |
Activating Compound |
Reference |
|---|
   5.6.1.7 | ammonium sulfate |
optimal functionality of MmGroEL/GroES and its ability to encapsulate larger proteins, such as malate dehydrogenase, requires the presence of ammonium sulfate in vitro |
669207 |
| 5.6.1.7 | ATP |
ATP is an allosteric ligand for GroEL, its binding promoting both cooperative (intra-ring) and anti-cooperative (inter-ring) actions. ATP serves as a substrate, undergoing hydrolysis during the reaction cycle to promote a unidirectional advance of the machine |
734473 |
| 5.6.1.7 | Co2+ |
- |
686717 |
| 5.6.1.7 | CoA |
- |
289225 |
| 5.6.1.7 | CoA |
4fold increase in activity with equimolar amount of CoA, 2.5fold increase in folding reactions containing tubulin target proteins |
289231 |
| 5.6.1.7 | Cpn10 |
- |
289221, 289223, 289225, 289230, 289233 |
| 5.6.1.7 | denatured beta actin |
4fold increase in ATPase activity at 30°C |
289225 |
| 5.6.1.7 | denatured beta tubulin |
- |
289225 |
| 5.6.1.7 | GroES |
- |
289216, 289218, 289220 |
| 5.6.1.7 | GroES |
an allosteric effector of ATP hydrolysis. GroES contact leads to large rigid-body apical movements that eject polypeptide into an enclosed folding chamber. Docking of GroES stabilizes the Rs-open state, taking this assembly to a more energetically stable state that is no longer reversible and that is committed to the further large movements to a final energetic minimum that is the fully domed end state |
734473 |
