Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search Activating Compound

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search
Image of 2D Structure
Search for synonyms (with exact matching search term)

Search term:

Results 1 - 10 of 16 > >>
download as CSV
download all results as CSV
EC Number Activating Compound Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.192',5'-linked oligoadenylates two different binding sites in the enzyme's ANK domain and a third site in the N lobe of the KH domain, sensing mechanism, structure-function analysis, overview. The KH/KH and kinase extension nuclease (KEN)/KEN interfaces are important in 2',5'-oligoadenylate-dependent enzyme activation 730967
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.192',5'-Oligoadenylate - 730509
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.192',5'-Oligoadenylate binds to and activates the enzyme. It is produced in response to viral double-stranded RNA by the 2',5'-oligoadenylate synthetase 730313
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.192',5'-Oligoadenylate mediates the enzyme activity, absolutely required for activity 730292
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.192',5'-Oligoadenylate the enzyme's pseudokinase domain is involved in the natural activator sensing, binding site and structure, modeling, overview. Quantitative determination of specific binding of the full-length enzyme and of isolated enzyme ANK domain to immobilized biotinylated 2',5'-oligoadenylate 730393
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.192',5'-oligoadenylates 2-5A 683943
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.192'-5'-linked oligoadenylates natural 2'-5'-linked tetraadenylates and three tetramers with 3'-end AMP units replaced with ribo-, arabino- and xylo-configured phosphonate analogues of AMP are enzyme activators with equal potency. The enzyme is activated by the binding of 2'-5'-linked oligoadenylates to the N-terminal ankyrin repeat domain, which causes the inactive monomer to form a catalytically active homodimer 729281
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.192'-5'-oligoadenylate short polyadenylate molecules that are connected by unique 2'-5' linkages, collectively referred to as 2-5A. 2-5A induces dimerization via the ANK domain and this dimerization correlates with activation of ribonuclease activity 729297
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.19citrate 25 mM sodium citrate buffer results in 170% activity compared to 100% activity in sodium acetate buffer, both pH 5.6 656706
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.19MgCl2 stimulates DNA hydrolyzing activity 683981
Results 1 - 10 of 16 > >>
download as CSV
download all results as CSV