EC Number |
Activating Compound |
Reference |
---|
3.4.25.1 | 19S regulatory complex |
represents the major proteasome activator |
712918 |
3.4.25.1 | 19S regulatory particle |
- |
688337 |
3.4.25.1 | 3H-1,2-dithiole-3-thione |
tissue specific increase of the catalytic subunits of the proteasome following oral administration of 0.5 mmol/kg |
688760 |
3.4.25.1 | aflatoxin G1 |
specific stimulator of activity |
685443 |
3.4.25.1 | Blm10 protein |
- |
688337 |
3.4.25.1 | chymostatin |
0.05 mg/ml, activation to 170% of the original activity, peptidyl-glutamyl-peptide-hydrolyzing activity, hydrolysis of benzyloxycarbonyl-LLE-2-naphthylamide |
649428 |
3.4.25.1 | doxorubicin |
apoptosis inductor doxorubicin increases enzymatic activities, regulates subunit composition, and phosphorylation state of 26S proteasomes |
685994 |
3.4.25.1 | histone H3 |
slective activation of the branched-chain amino acid preferring activity with benzyloxycarbonyl-GPALG-4-aminobenzoate as substrate, 1000% |
650040 |
3.4.25.1 | KYFTGSKLWRSYYA |
peptidic activator, based on the Blm10 activator of 20S proteasome. At 10 microM concentration, chymotrypsin-like and peptidylglutamyl peptide hydrolyzing activities increase around three times whereas trypsin-like activity increases around 7fold |
755477 |
3.4.25.1 | leupeptin |
0.05 mg/ml, activation to 125% of the original activity, peptidyl-glutamyl-peptide-hydrolyzing activity, hydrolysis of benzyloxycarbonyl-LLE-2-naphthylamide |
649428 |