EC Number   |
Activating Compound |
Reference |
|---|
   3.4.24.71 | captopril |
solECE, activity 106.9% |
649414 |
| 3.4.24.71 | chymostatin |
- |
651235 |
| 3.4.24.71 | E-64 |
- |
651235 |
| 3.4.24.71 | K49-P1-20 |
i.e. N-terminal domain of Bothrops asper myotoxin II, 2fold enhancement of enzyme activity (maximal stimulation with 0.0001 mg/ml), activation concentration 50 (AC50) is 0.00192 mM |
755423 |
| 3.4.24.71 | more |
diabetes and radiocontrast media increase medullary, but not cortical endothelin converting enzyme-1 content in the kidney, in vivo, the induction of diabetes or the administration of contrast media rises the enzyme activity 4-5fold, but 15fold when diabetic rats are given contrast media, the in vitro activity is increased 3-4fold, overview |
683837 |
| 3.4.24.71 | more |
enzyme expression is twofold increased during transfer from seawater to freshwater, and sixfold during transfer from freshwater to seawater, while chronic exposure to fresh- or seawater has no effet on the enzyme, overview |
683713 |
| 3.4.24.71 | more |
protein kinase C epsilon, PKCepsilon, stimulates ECE-1 activity, overview |
684002 |
| 3.4.24.71 | more |
protein kinase C epsilon, PKCepsilon, stimulates the amyloid-beta peptide degradation by ECE-1 in transgenic mice, overview |
684002 |
| 3.4.24.71 | more |
the peptidase inhibitor CGS-26303, bigendothelin-1, and phosphoramidon, though not thiorphan, a neutral endopeptidase inhibitor, increase endothelin converting enzyme-1 expression in endothelial cells through accumulation of big endothelin-1, CGS-26303 and big endothelin increase ECE-1 promoter activity, the stimulation is abolished by cycloheximide, overview |
683318 |
| 3.4.24.71 | pepstatin A |
- |
651235 |
