EC Number   |
Activating Compound |
Reference |
|---|
   3.4.24.7 | 15-deoxy-DELTA12,14-prostaglandin J2 |
treatment of with 30 mM of 15-deoxy-DELTA12,14-prostaglandin J2 increases the expression of heme oxygenase-1, which precedes the induction of matrix metalloproteinases. The 15-deoxy-DELTA12,14-prostaglandin J2-induced upregulation of MMP-1 is abrogated by the heme oxygenase-1 inhibitor zinc protoporphyrin IX as well as introduction of heme oxygenase-1 short interfering RNA |
697142 |
| 3.4.24.7 | 4-aminophenylmercuric acetate |
MMP-1 from synovial fibroblasts is activated with 10 mM 4-aminophenylmercuric acetate in 0.1 N NaOH at 37 °C for 3 h |
709789 |
| 3.4.24.7 | glucose |
presence of high glucose levels and interferon gamma in culture medium have a synergistic effect on the expression of matrix metalloproteinases MMP-1, MMP-9 and interleukin-1beta. High glucose also enhances interferon gamma-induced priming effect on lipopolysaccharide-stimulated MMP-1 secretion. High glucose and interferon gamma exert the synergistic effect on MMP-1 expression by enhancing STAT1 phosphorylation and STAT1 transcriptional activity |
695964 |
| 3.4.24.7 | interferon gamma |
presence of high glucose levels and interferon gamma in culture medium have a synergistic effect on the expression of matrix metalloproteinases MMP-1, MMP-9 and interleukin-1beta. High glucose also enhances interferon gamma-induced priming effect on lipopolysaccharide-stimulated MMP-1 secretion. High glucose and interferon gamma exert the synergistic effect on MMP-1 expression by enhancing STAT1 phosphorylation and STAT1 transcriptional activity |
695964 |
| 3.4.24.7 | interleukin-1 receptor antagonist |
increases active MMP-1 level |
707312 |
| 3.4.24.7 | more |
active MMP-10 does not cleave collagen type 1 directly, it does activate the collagenase MMP-1, EC 3.4.24.7. The ability of active MMP-10 to superactivate MMP-1 creates a plasmin/MMP-10/MMP-1 proteolytic axis effectively enhances collagen type 1 degradation |
707982 |
| 3.4.24.7 | more |
dexamethasone induces myocardial matrix degradation by MMP-1 |
683845 |
| 3.4.24.7 | more |
disruption of caveolae by addition of methyl-beta-cyclodextrin results in a dramatic decline in both motility and invasion abilities of cells with concomitant increase in secreted MMP-2 expression and expression levels of MMP-1 and MMP-9 |
696966 |
| 3.4.24.7 | more |
essential role of activator protein-1 activation in constitutive MMP1 overexpression in Xeroderma pigmentosum-C primary fibroblasts |
682206 |
| 3.4.24.7 | more |
proteasome blockade, regardless of the inhibitor used, e.g. proteasome inhibitor I, MG-132, lactacystin, or bortezomib, decreases the production of type I collagen and TIMP-1 and up-regulates that of MMP-1, overview |
683451 |
