EC Number   |
Activating Compound |
Reference |
|---|
   3.4.24.23 | Brij-35 |
activates MMP-7 in a broad concentration range, but inhibits at high concentration |
707115 |
| 3.4.24.23 | Cholesterol sulfate |
selectively alters substrate preference of matrix metalloproteinase-7 and promotes degradations of pericellular laminin-332 and fibronectin. Degradation of laminin-332 (laminin-5) catalyzed by MMP-7 is accelerated dramatically in the presence of cholesterol sulfate, whereas the sulfated lipid inhibits the degradation of casein catalyzed by the protease. Cholesterol sulfate facilitates the proteolyses by cross-linking MMP-7 to its substrates, mechanism, overview |
717801 |
| 3.4.24.23 | Fas ligand |
treatment with Fas ligand, Fas-L, increases levels of active MMP-7 by 80% |
708021 |
| 3.4.24.23 | heparin |
enhances activity 15fold |
652071 |
| 3.4.24.23 | heparin |
porcine intestinal heparin, increases activity by decreasing the Km value, increases the enzyme's thermostability |
733534 |
| 3.4.24.23 | more |
angiogenesis and apoptosis do not influence MMP-7 expression in lung cancer cells, overview |
683843 |
| 3.4.24.23 | more |
binding of matrilysin-1 to epithelial cells via cholesterol sulfate, protamine or heparin promotes its activity and renders the enzyme resistant to TIMP-2, overview |
683345 |
| 3.4.24.23 | more |
cholesterol, dehydroepiandrosterone sulfate, and heparin do not affect MMP-7-catalyzed degradations of fibronactin and laminin-332 |
717801 |
| 3.4.24.23 | more |
enzyme expression is upregulated in kidneys that are MHC-incompatible allografts but are tolerated through induction by the administration of anti-donor class II antibodies, as part of the pivotal non-canonical wingless-type signaling pathway, overview |
683742 |
| 3.4.24.23 | more |
estrogen stimulates activation of the pro-MMP-7 intracellularly in the Golgi apparatus and augments secretion of the activated MMP-7 form, steady-state levels of MMP-7 mRNA and protein are not affected by estrogen, monensin, but not tunicamycin and brefeldin-A, blocks estrogen effects, overview, estrogen increases co-immunoreactivity of MMP-7 with synaptosomal-associated protein of 25 kDa in apical membranes, bafilomycin A1 inhibits activation of MMP-7 |
683413 |
