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EC Number
Activating Compound
Commentary
Reference
3.4.23.5
ATP
385.5% activity at 1 mM
717693
3.4.23.5
DELTA9-tetrahydrocannabinol
at 10 nM, almost doubles enzyme activity in cell culture
651543
3.4.23.5
ethanol
in 10% (v/v) ethanol, the enzyme significantly increases its activity by 50%
753835
3.4.23.5
H2O2
slight activation
36943
3.4.23.5
Isopropanol
the presence of 15% (v/v) isopropanol generates a significant increase of 80% on enzyme activity
753835
3.4.23.5
methanol
exposure of the enzyme to 5-15% (v/v) methanol produces 50% increase in enzyme activity
753835
3.4.23.5
multi-granulin domain peptide
-
752788
3.4.23.5
progranulin
-
752788
3.4.23.5
progranulin
stimulates the in vitro maturation of the proenzyme at acidic pH
754432
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