EC Number |
Activating Compound |
Reference |
---|
3.4.22.64 | cholera toxin B |
a caspase-11-activating toxin |
731613 |
3.4.22.64 | more |
activation through dimerization. Signaling pathways involved in caspase-11 activation, overview |
731613 |
3.4.22.64 | more |
Bacterial infection triggers caspase-11 activation , and intracellular lipopolysaccharide triggers caspase-11 activation, Toll-like receptor 4 is dispensable for caspase-11 triggering by cytoplasmic lipopolysaccharide, mechanism, detailed overview |
731905 |
3.4.22.64 | more |
benzene, increase of caspase-4 expression after 12 days of oral benzene treatment to p53KO mice |
695936 |
3.4.22.64 | more |
caspase-11 is activated by a cytosolic sensing mechanism that detects bacterial-derived signals delivered into the host cytosol through the type IV secretion apparatus. Caspase-11 activation by Legionella pneumophila has distinct kinetic and molecular parameters, overview. Caspase-11 activation requires upstream protein(s) capable of sensing a microbial or endogenous danger signal. Caspase-11 requires type I IFN production mediated by TRIF-dependent TLR signaling. And caspase-1 is dispensable for caspase-11-dependent pyroptosis induced by Legionella pneumophila |
732823 |
3.4.22.64 | more |
the adaptor protein TRIF upregulates procaspase-11 expression, and this upregulation is required for caspase-11 processing and activation. Lipopolysaccharide treatment or type I IFN treatment alone does not cause caspase-11-dependent cell death |
731611 |
3.4.22.64 | more |
the cholera toxin B subunit and many different Gram-negative bacteria can trigger Caspase-11 activation in vitro. Cytosolic infection of cells with Burkholderia species and cytyosolic mutants of Salmonella typhimurium and Legionella pneumophila trigger the enzyme |
732915 |