EC Number   |
Activating Compound |
Reference |
|---|
   3.4.22.59 | adriamycin |
increases caspase-6 mRNA levels in HCT116 p53+ and neo cells but not in E6 cells |
670722 |
| 3.4.22.59 | caspase-1 |
caspase-1 activates caspase-6 in vitro |
668193 |
| 3.4.22.59 | etoposide |
mild induction of the enzyme in HCT116 p53+ cells |
670722 |
| 3.4.22.59 | more |
activation of CASP6 in response to ischemia-induced injury. Activation by proteolytic self-cleavage, during activation, the N-terminal prodomain is removed by cleavage at a TETD site. Double cleavage in an unstructured linker region at a DVVD and a TEVD site gives rise to a large 20-kDa and a small 10-kDa subunit. The two large p20 and two small p10 subunits then assemble to form the active CASP6 complex |
718437 |
| 3.4.22.59 | more |
caspase-6 can be entirely self-activated through self-processing, the prodomain of Casp6 entirely prevents self-processing and activation in vivo but not in vitro, removal of the pro-domain promotes Casp6 activation |
696453 |
| 3.4.22.59 | more |
cell stress induced by staurosporine results in the nuclear translocation and activation of caspase-6 |
698177 |
| 3.4.22.59 | more |
glycochenodeoxycholic acid induces activation of caspase-6, which is inhibited by inhibition of caspase-9 |
698943 |
| 3.4.22.59 | more |
ZBP-89, a Kruppel-type, zinc finger transcription factor, induces caspase-6 activation leading to inhibition of cell death in hepatoccellular carcinoma cells, inhibition of caspase-6 abolishes the effect of ZBP-89 |
697089 |
| 3.4.22.59 | P53 |
- |
670722 |
| 3.4.22.59 | RCasp1 |
mediates increased self-processing of pro-Casp6a into its active subunits |
717804 |
