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EC Number
Activating Compound
Commentary
Reference
3.4.21.27
activated factor IX
autoactivation, cleavage of FXI at the Arg369-Ile370 bond. activated factor IX is part of a feedback loop that sustains thrombin generation through FIX activation to consolidate coagulation
707856
3.4.21.27
activated factor VII
-
707308
3.4.21.27
activated factor XI
-
709721
3.4.21.27
activated factor XII
activated factor XII-mediated activation of FXI appears to play a central role in formation of pathologic thrombi in murine thrombosis models
707856
3.4.21.27
activated factor XII
activates its substrate FXI
709722
3.4.21.27
activated factor XII
cleaves FXI at the Arg369-Ile370 bond
707856
3.4.21.27
activated factor XII
FXI activation proceeds through an intermediate with only one activated submit
709721
3.4.21.27
alpha-thrombin
cleaves FXI at the Arg369-Ile370 bond
707856
3.4.21.27
desmopressin
-
707308
3.4.21.27
desmopressin
increase of both FXI activity (up to 31%) and antigen levels 60 min after infusion. Also contradictory results with a lack of rise of FXI levels after infusion
707148
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