EC Number |
Activating Compound |
Reference |
---|
3.1.4.17 | 2-mercaptoethanol |
stimulates |
135213 |
3.1.4.17 | ascorbic acid |
reduced, slight stimulation |
135232 |
3.1.4.17 | ascorbic acid |
stimulates |
135213 |
3.1.4.17 | Ca2+ |
isoform PDE1, stimulation of both hydrolysis of cAMP and cGMP |
681548 |
3.1.4.17 | Calmodulin |
differential effect on isozymes, activation only in complex with Ca2+, overview |
651468 |
3.1.4.17 | Calmodulin |
isoform PDE1, stimulation of both hydrolysis of cAMP and cGMP |
681548 |
3.1.4.17 | cGMP |
about 30fold stimulation of isoform PDE2A with EC50 value of 0.0011 mM |
679247 |
3.1.4.17 | cGMP |
binding of cGMP to GAF domains within PDE2 results in the activation of all PDE2 variants |
716435 |
3.1.4.17 | cGMP |
PDE2 is stimulated by cGMP |
692191 |
3.1.4.17 | clozapine |
chronic treatment with 20 mg/kg clozapine increases PDE10A expression by 62% |
694373 |