EC Number   |
Activating Compound |
Reference |
|---|
   3.1.3.17 | 2-mercaptoethanol |
maximal activation at 50 mM, absolute requirement for SH compounds |
94688 |
| 3.1.3.17 | ascorbic acid |
maximal activation at 1 mM |
94688 |
| 3.1.3.17 | dithiothreitol |
maximal activation at 1 mM, absolute requirement for SH compounds |
94688 |
| 3.1.3.17 | ethanol |
80% ethanol, activation of both isoenzymes, conversion of isoenzyme H-1 to a 35500 Da form and isoenzyme H-2 to a 67000 Da form and a 35500 Da form |
94685 |
| 3.1.3.17 | glucose |
50 mM, activates |
94691 |
| 3.1.3.17 | glucose 6-phosphate |
0.25 mM, activates |
94691 |
| 3.1.3.17 | Insulin |
induces the enzyme in diabetic rats |
649721 |
| 3.1.3.17 | more |
the 200000 Da latent enzyme form Fc can be activated with either ATPMg2- and an activating factor Fa or by Mn/trypsin treatment |
94685 |
| 3.1.3.17 | more |
the inactive enzyme can be activated in two ways: 1. by limited proteolysis with trypsin in presence of Mn2+, 2. activation by an MgATP2--dependent reaction, that also requires a factor known as Fa, which appears to be identical to glycogen synthase kinase-3 |
94680 |
| 3.1.3.17 | p-nitrophenyl phosphate |
slight stimulation |
94698 |
