EC Number |
Activating Compound |
Reference |
---|
2.8.2.15 | celecoxib |
heterotrophic modulator, switches sulfation from the 3-O-position to the 17beta-O-position and activates such that the total sulfated product exceed product formation by the native enzyme, 3fold to 4fold at 0.25 mM celecoxib |
661577 |
2.8.2.15 | more |
enzyme induction by 1alpha,25-dihydroxyvitamin D3 via the vitamin D responsive element C/ERB-alpha, but not C/ERB-beta, coactivators p300, steroid receptor coactivator 1 and 2, SRC-1 and SRC-2, but not SRC-3, are also required, overview |
675998 |
2.8.2.15 | more |
induction of SULT2A1 expression by xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR, aging has no effect on the activity of an IR0 enhancer in the Sult2A1 chromatin to recruit VDR, RXR-alpha, and PXR in mice injected with D3 or PCN |
673838 |
2.8.2.15 | more |
lithocholic acid induces SULT2A in wild-type and farnesoid X receptor-null mice, chenodeoxycholic acid induces the enzyme only in farnesoid X receptor-null mice, not in wild-type mice, overview |
673311 |
2.8.2.15 | more |
methotrexate induces SULT2A1 expression via nuclear receptor interactions, molecular mechanism, overview, the constitutive active receptor, CAR, mediates the methotrexate induction of SULT2A1 in both Caco-2 and Hep G2 cells, vitamin D receptor, VDR, also upregulates SULT2A1 gene expression, CAR inhibits VDR-mediated vitaminD3 induction of SULT2A1 but notmethotrexate induction of SULT2A1, overview |
674394 |
2.8.2.15 | more |
SULT2A1 is a target gene for metabolic regulation/induction by thyroid hormone T3, T3 overexpressing cell s show increased SULT2A1 expression, indirect regulation mechanism via the transcription factor steroidogenic factor 1, SF1, overview |
673350 |
2.8.2.15 | more |
the enzyme promoter contains composite elements inducible by nuclear receptors pregnane X receptor and constitutive androstane receptor, synergizing effects by HNF4alpha binding at a site near the promoter, overview |
676007 |