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EC Number Activating Compound Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86DNA the cyclase activity is stimulated by DNA but not by RNA 723773
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86dsDNA cGAS is activated by dsDNA, a site for small molecule binders may cause cGAS activation at physiological ATP concentrations. dsDNA in the cytosol may occur from infection or mitochondrial damage 762338
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86dsDNA presence of dsDNA activates cGAS. dsDNA of 12 bp in length does not activate mcGAS efficiently, dsDNA of 18 bp in length has about 90% activity compared to salmon sperm DNA. Interactions of both DNA binding aites are essential for activation. The two sites bind cooperatively and site B plays a crucial role in binding. DNA binding by induces higher-order complex formation in solution 738356
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86Plasmodium falciparum genomic DNA activates cGAS in vivo in THP-1 cells, no effect in enzyme-deficient cGAS-/- THP-1 cells. 2',3'-cGAMP is produced in Pf gDNA-transfected THP-1 cells but not in control THP-1 cells 761638
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