EC Number   |
Activating Compound |
Reference |
|---|
   2.7.7.8 | AMP |
1.6 mM, 30% activation of ADP polymerization |
643687 |
| 2.7.7.8 | Basic polypeptide |
peptide from Escherichia coli extract, enhances ADP-phosphate exchange |
643680 |
| 2.7.7.8 | Bis-(3-aminopropyl)-amine |
optimal polymerization activity requires presence, 2fold increase in activity at 30 mM |
643694 |
| 2.7.7.8 | citrate |
a PNPase-mediated response to citrate, and PNPase deletion broadly impacts on the metabolome. PNPase-dependent cells show reduced growth in the presence of increased citrate concentration. In vitro, citrate directly binds and modulates PNPase activity, and the enzyme is inhibited by binding of metal-chelated citrate, predominantly complexed as magnesium-citrate, in the active site at physiological concentrations. In the contrary, metal-free citrate is bound at a vestigial active site, where it stimulates PNPase activity, this vestigial site as an allosteric binding pocket that recognizes metal-free citrate |
722702 |
| 2.7.7.8 | cytidyldadenylate dinucleoside |
activates GDP polymerization |
643699 |
| 2.7.7.8 | diphosphate |
activation of PNPase RNA synthesis activity at very low concentrations of phosphate |
643706 |
| 2.7.7.8 | dithiothreitol |
similar activation as with 2-mercaptoethanol |
643694 |
| 2.7.7.8 | interferon-beta |
close association between interferon-beta induced upregulation of enzyme and c-myc downregulation |
672972 |
| 2.7.7.8 | KCl |
400 mM, 5fold activation of ADP polymerization |
643699 |
| 2.7.7.8 | KCl |
maximal activation at 300 mM |
643685 |
