EC Number |
Activating Compound |
Reference |
---|
2.7.11.30 | actividin |
activates Smad2 phosphorylation via type I receptor kinases |
663984 |
2.7.11.30 | actividin |
binds and activates the type I receptor ALK7 |
664721 |
2.7.11.30 | actividin |
TGF-beta receptor I and ALK7 possess an actividin receptor-binding domain |
664282 |
2.7.11.30 | actividin A |
required for activity in a complex formed with ALK4 and ActRIIB or ActRII, identification of the functional binding site |
665487 |
2.7.11.30 | actividin B |
required for activity in a complex formed with ALK4 and ActRIIB or ActRII, identification of the functional binding site |
665487 |
2.7.11.30 | ALK5 |
is important for ALK1/TGF-beta signaling |
666312 |
2.7.11.30 | growth differentiation factor-9 |
i.e. GDF-9, interacts with bone morphogenetic protein type II receptor, and activates type I actividin receptor-like kinase 5, ALK5, GDF-9 belongs to the TGF-beta family, no stimulation of receptors ALK1, ALK2, ALK3, and ALKA6 by GDF-9 |
666359 |
2.7.11.30 | more |
increased D-glucose and palmitate concentrations increase the ALK7 enzyme expression in INS-1 cells |
664721 |
2.7.11.30 | nodal |
- |
664282 |
2.7.11.30 | SARA protein |
i.e. Smad anchor for receptor activation protein, binding site for co-modulator Smad4, modulates self-association of partially phosphorylated Smad2 preventing premature release of monophosphorylated substrate, interaction with Smad2 via the Smad2 MH2 domain |
664036 |