EC Number   |
Activating Compound |
Reference |
|---|
    2.7.1.74 | 1-beta-D-arabinosylcytosine |
i.e. cytarabine, 0.001 mM, stimulation |
641956 |
| 2.7.1.74 | 2'-deoxyadenosine/deoxycoformycin |
no stimulation of enzyme activity by either compound if applied alone, with both compound at 0.01 mM 2.4fold activation occurs |
660812 |
| 2.7.1.74 | 2'-deoxythymidine-5'-thiosulphate |
in intact cells, activation, reversed by 2-deoxycytidine |
641973 |
| 2.7.1.74 | 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine |
0.001 mM, stimulation |
641956 |
| 2.7.1.74 | 2-chloro-2'-deoxy-2'-fluoro-arabinosyladenine |
stimulation |
641968 |
| 2.7.1.74 | 2-chloro-2'-deoxyadenosine |
- |
671908, 671911 |
| 2.7.1.74 | 2-chloro-2'-deoxyadenosine |
2.4fold activation at 0.003 mM, activation is slightly inhibited by 3-aminobenzamide, the activation of the enzyme is a first step in 2-chloro-2'-deoxyadenosine-induced cytotoxicity |
660812 |
| 2.7.1.74 | 2-chloro-2'-deoxyadenosine |
i.e. cladribine, 0.001 mM, stimulation |
641956 |
| 2.7.1.74 | 2-chloro-2'-deoxyadenosine |
increases activity by increasing phosphorylation of Ser74 |
672894 |
| 2.7.1.74 | 2-chloro-2'-deoxyadenosine |
up to 0.01 mM, up to 4fold increase in activity |
641968 |
