EC Number   |
Activating Compound |
Reference |
|---|
   2.7.1.105 | ATP |
the binding of ATP to the fructose 2,6-bisphosphatase domain of chicken liver 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase leads to activation of enzyme, but no activation of rat liver enzyme |
640339 |
| 2.7.1.105 | glucose |
inhibition by N-bromoacetylethanolamine |
640336 |
| 2.7.1.105 | Insulin |
activation of transfected heart enzyme in human embryonic kidney 293 cells by inducing the phosphorylation of Ser466 and Ser483, activation is mediated by 3-phosphoinositide-dependent kinase-1, protein kinase B is in vivo not essential, activation is sensitive to LY294002 and wortmannin and insensitive to rapaycin and PD98059 |
640343 |
| 2.7.1.105 | Insulin |
stimulates glycolysis in the heart by increasing glucose transport and activating H-PFK2 by phosphorylating Ser466 and Ser483 through protein kinase B within the C-terminal regulatory domain. Phosphorylation of Ser466 or Thr475 by protein kinase C does not change the enzyme activity. Phosphorylation at Ser84 possibly counteracts the effects of phosphorylation at the activating C-terminal sites |
737973 |
| 2.7.1.105 | iodoacetamide |
- |
640292 |
| 2.7.1.105 | iodoacetamide |
activation, kidney and liver, not heart or testis enzyme |
94935 |
| 2.7.1.105 | more |
amino acids increase beta-D-fructose 2,6-bisphosphate concentration in HeLa and in MCF-7 human cells, molecular mechanisms involved differ from those observed with insulin. Only essential amino acids without glutamine are required to activate the PI3K/mTORC2 and p38/MAPKAPK-2 pathways and to increase the beta-D-fructose 2,6-bisphosphate concentration. The observed effects in signaling and metabolism are produced by a mixture of essential amino acids |
730008 |
| 2.7.1.105 | more |
amino acids increase beta-D-fructose 2,6-bisphosphate concentration in primary cardiomyocytes, molecular mechanisms involved differ from those observed with insulin. Only essential amino acids without glutamine are required to activate the PI3K/mTORC2 and p38/MAPKAPK-2 pathways and to increase the beta-D-fructose 2,6-bisphosphate concentration. The observed effects in signaling and metabolism are produced by a mixture of essential amino acids |
730008 |
| 2.7.1.105 | more |
one enzyme form is activated dramatically as result of modification by MgATP during preincubation |
94929 |
| 2.7.1.105 | pyruvate |
- |
640338 |
