EC Number   |
Activating Compound |
Reference |
|---|
    2.3.1.24 | CHAPS |
required |
720407 |
| 2.3.1.24 | daunorubicin |
an anthracycline used in the treatment of leukemia, increases the enzyme activity and ceramide production, and inhibits the apoptosis of leukmeia cells |
753169 |
| 2.3.1.24 | daunorubicin |
an anthracycline used in the treatment of leukemia, increases the enzyme activity and ceramide production, and inhibits the apoptosis of leukmeia cells, 70% increase of activity in microsomes at 0.01 mM in treatment of cell cultures for 6 h |
753169 |
| 2.3.1.24 | more |
addition of phosphatidylserine-liposomes increases the enzyme activity by 6.7%. Phospholipid-containing liposomes are potent stimulators of the enzyme, best is phosphatidylserine in liposomes, suggesting an important role of the net negative charges, overview |
752899 |
| 2.3.1.24 | more |
exposure of cells to hypoxia-reoxygenation results in a significant increase in ceramide synthase activity |
752435 |
| 2.3.1.24 | more |
vincristine (100 nM), methotrexate (200 nM), etoposide (0.003 mM), and cis-platinum (0.05 mM) do not stimulate ceramide synthase |
753169 |
| 2.3.1.24 | N-(4-hydroxyphenyl)retinamide |
i.e. 4-HPR or fenretinide, elevates ceramide in neuroblastoma cell lines by coordinating activation of serine palmitoyltransferase and ceramide synthase. 4-HPR treatment does not accelerate cellular decay of sphingomyelin |
753141 |
