EC Number   |
Activating Compound |
Reference |
|---|
   1.5.1.6 | 2-mercaptoethanol |
5 to 15 mM: 1.7fold increase in activity, higher concentrations have no further effect, it may reduce oxidized Cys-707 or another important sulfhydryl group |
392342 |
| 1.5.1.6 | 2-mercaptoethanol |
dehydrogenase and hydrolase activities are dependent on the presence of high concentrations of 2-mercaptoethanol to prevent the oxidative degradation of the substrate 10-formyltetrahydrofolate |
392351 |
| 1.5.1.6 | 2-mercaptoethanol |
optimal dehydrogenase activity requires 15 mM or higher concentrations |
392352 |
| 1.5.1.6 | 4'-phosphopantetheinyl transferase |
4'-phosphopantetheinyl transferase activates dehydrogenase catalysis of ALDH1L2 by modifying Ser375 |
724712 |
| 1.5.1.6 | C1-tetrahydrofolate synthase |
10-formyltetrahydrofolate synthetase activity of trifunctional enzyme causes together with its substrates MgATP, formate, and tetrahydrofolate an 3fold increase of initial velocity |
392349 |
| 1.5.1.6 | more |
not activated by methionine or ethionine |
392341 |
| 1.5.1.6 | NADPH |
activates |
392344, 392349 |
| 1.5.1.6 | NADPH |
activates at concentrations and in ratio with NADP+ consistent with those in rat liver in vivo, activation is associated with higher Ki-value for tetrahydrofolate |
392341 |
| 1.5.1.6 | serine hydroxymethyltransferase |
addition of SHMT and of its substrate L-serine increases the initial reaction rate by 1.8fold with 10-formyltetrahydropteroylpentaglutamate as substrate, SHMT increases the release of product |
392349 |
